We aim at uncovering the molecular mechanisms underlying signaling specificity and cellular outputs during breast cancer progression and metastasis. We focus on:
*exploring how the trafficking of receptor tyrosine kinases (RTKs) from and to the plasma membrane can elicit specific cellular responses, such as cell migration and invasion;
*characterizing the signaling networks underlying breast cancer metastasis in organoids and patient-derived samples.
We use a “functional proteomics” approach, which integrates quantitative mass-spectrometry-based (phospho) proteomics, bioinformatics analysis, functional assays, and advanced imaging techniques (see picture).
The final goal is to identify and characterize proteins with key roles in cellular signaling that can be targeted for personalized intervention in breast cancer patients.
“Functional Proteomics” workflow.
Current Group Members
Dr Michael P. Smith
Jennifer Ferguson Haworth
Co-supervised PhD students
Tom Kedward – Funded by BRC (2017-2021). Co-supervised with Dr Robert Clarke and Dr Sasha Howell (MCRC, Manchester)
Chris Jones – Funded by LICAP (2017-2021). Co-supervised with Prof Andy Sharrocks (The University of Manchester) and Prof John Ladbury (University of Leeds)
Sam Odgen – Funded by Wellcome Trust MCB programm (2017-2021). Co-supervised with Prof Andy Sharrocks (The University of Manchester).
Emily Goodall – Funded by BBSRC (2019-2023). Co-supervised with Dr Pat Caswell and Dr J-m Schwartz (The University of Manchester).
Previous Group Members
C. Bates, Wellcome Trust MCB PhD student (Oct – Dec 2016); B. Hale, UG (Dec 2016 – Mar 2017); R. Yarwood, Wellcome Trust MCB PhD student (Jan – March 2017); J. Bowles, Wellcome Trust QBB PhD student (Oct 2017 – Feb 2018); C. Goncalves, Wellcome Trust MCB PhD student (Jan – March 2018); S. Saleh, UG (Dec 2017 – Apr 2018); Dr K. Kowalczyk, RA (2016-2018); H. Sun, technician (Feb – Oct 2018); S. Chandler, UG (Dec 2018 – Apr 2019); R. Brady, Wellcome Trust MCB PhD student (Apr – July 2018); N. Alachkar, Wellcome Trust QBB PhD student (Apr 2018 – July 2018); A. Asante-Sakyi UG (Jan- March 2018)
Dr Arndt Rohwedder, University of Leeds (June 2017 – July 2018)